Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat
Identifieur interne : 004711 ( Main/Exploration ); précédent : 004710; suivant : 004712Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat
Auteurs : François B. Jolicoeur [Canada] ; Robert Rivest [Canada] ; Andrea Drumheller [Canada]Source :
- Brain Research Bulletin [ 0361-9230 ] ; 1991.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 3,4-Dihydroxyphenylacetic Acid (metabolism), Animal, Animals, Brain (metabolism), Degenerative disease, Dopamine, Dopamine (metabolism), Dyskinesia, Drug-Induced (metabolism), Dyskinesia, Drug-Induced (physiopathology), Experimental disease, Homovanillic Acid (metabolism), Humans, Hydroxydopamines (pharmacology), Hypokinesia, Hypothalamus, Hypothalamus, Posterior (drug effects), Hypothalamus, Posterior (physiopathology), Male, Muscle Rigidity (chemically induced), Nervous system diseases, Oxidopamine, Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Parkinson disease, Rat, Rats, Stiffness, Tremor, Tremor (chemically induced).
- MESH :
- chemical , metabolism : 3,4-Dihydroxyphenylacetic Acid, Dopamine, Homovanillic Acid.
- chemically induced : Muscle Rigidity, Tremor.
- drug effects : Hypothalamus, Posterior.
- metabolism : Brain, Dyskinesia, Drug-Induced, Parkinson Disease.
- chemical , pharmacology : Hydroxydopamines.
- physiopathology : Dyskinesia, Drug-Induced, Hypothalamus, Posterior, Parkinson Disease.
- Animals, Humans, Male, Oxidopamine, Rats.
Abstract
Bilateral administration of 6-hydroxydopamine in the medial forebrain bundle at the level of the posterolateral hypothalamus in rats resulted in hypokinesia, muscular rigidity and tremor as determined by various behavioral assessment procedures. These neurological signs were accompanied by marked decreases in the concentrations of dopamine and its main metabolites dihydroxyphenylacetic acid and homovanillic acid in both striatum and nucleus accumbens. Administration of apomorphine (1 mg/kg) or L-Dopa (60 mg/kg) reversed or totally abolished the hypokinesia, rigidity and tremor in lesioned animals. Together, the present findings demonstrate that bilateral intrahypothalamic administration of 6-OHDA results in the appearance of the three cardinal symptoms of Parkinson's disease in rats. This model should prove to be valuable for both the study of the neuropathological processes underlying the neurological signs of this disease and the screening of potential antiparkinson agents.
Url:
DOI: 10.1016/0361-9230(91)90245-F
Affiliations:
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Le document en format XML
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These neurological signs were accompanied by marked decreases in the concentrations of dopamine and its main metabolites dihydroxyphenylacetic acid and homovanillic acid in both striatum and nucleus accumbens. Administration of apomorphine (1 mg/kg) or L-Dopa (60 mg/kg) reversed or totally abolished the hypokinesia, rigidity and tremor in lesioned animals. Together, the present findings demonstrate that bilateral intrahypothalamic administration of 6-OHDA results in the appearance of the three cardinal symptoms of Parkinson's disease in rats. This model should prove to be valuable for both the study of the neuropathological processes underlying the neurological signs of this disease and the screening of potential antiparkinson agents.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Jolicoeur, Francois B" sort="Jolicoeur, Francois B" uniqKey="Jolicoeur F" first="François B." last="Jolicoeur">François B. Jolicoeur</name></noRegion><name sortKey="Drumheller, Andrea" sort="Drumheller, Andrea" uniqKey="Drumheller A" first="Andrea" last="Drumheller">Andrea Drumheller</name><name sortKey="Rivest, Robert" sort="Rivest, Robert" uniqKey="Rivest R" first="Robert" last="Rivest">Robert Rivest</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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